Exemestane CAS107868-30-4
Price | USD1746.00 |
Packge | 500g |
- Min. Order:500g
- Supply Ability:1T
- Time:2022-06-06
Product Details
- Product NameExemestane
- CAS No.107868-30-4
- EINECS No.643-090-2
- MFC20H24O2
- MW296.4
- Appearancepowderwhite to off-white
- Melting point 155.13°C
- storage temp. 2-8°C
- Boiling point 453.7±45.0 °C(Predicted)
- density 1.13±0.1 g/cm3(Predicted)
Product Name: Exemestane
Synonyms: ExeMestane (USP);ExeMestane(AroMasin);1,4-Androstadien-3,17-dione-6-Methylene-d2;(8R,9S,10R,13S,14S)-10,13-Dimethyl-6-methylene-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17(10H,14H)-dione;ExeMestine;(8R,9S,10R,13S,14S)-10,13-diMethyl-6-Methylene-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione;ExeMestane SynonyMs 6-Methylenandrosta-1,4-diene-3,17-dione;PNU155971
CAS: 107868-30-4
MF: C20H24O2
MW: 296.4
Description
Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity. It is the first steroidal representative of the third-generation of orally active aromatase inhibitors with a highly potent and selective mechanism of action, displaying good tolerability and safety profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally advanced or metastatic disease. In addition, it may also have potential for breast cancer prevention.
Company Profile Introduction
Baoji Guokang Health Chemical Technology Co., Ltd has a subsidiary, Baoji Guokang Bio-Technology Co., Ltd. It is located in Baoji High-tech Zone,with epitomizing international, cooperative and honest. We are a young company full of action and energy, our profession improves us rapid progress, which satisfy our clients both in home and abroad. We are specialized in API's intermediates, fine chemicals and plant extracts.We toughly insist on that quality is always the most important item not only for us, but also for our clients. It is believed that we could be considered as the most powerful man in the area of chemicals with combined strength in R&D and Marketing. We are a "customer first" company and believe that our success depends on double-wins.our customers are from more than 160 countries worldwide ,we work closely with every customer to support high quality business service. Our target purpose is "provide favorable value,convenient and flexible solutions for you."we promise: reasonable prices, short supplying period and satisfactory after-sales service. Buyers are welcome to contact us !
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- Since:2018-09-06
- Address: Room B801, Financial Plaza, Jintai District, Baoji, Shaanxi, CN