Sunitinib CAS 557795-19-4
Price | USD160.00 |
Packge | 20g/Bag |
- Min. Order:20g
- Supply Ability:100KG
- Time:2022-06-06
Product Details
- Product NameSunitinib
- CAS No.557795-19-4
- EINECS No.251-228-4
- MFC22H27FN4O2
- MW398.47
- AppearanceSolidYellow to Dark Orange
- Melting point 189-191°C
- density 1.2
- Boiling point 572.1±50.0 °C(Predicted)
- storage temp. 2-8°C
Product Name: Sunitinib
CAS: 557795-19-4
MF: C22H27FN4O2
MW: 398.47
Description
Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC50 values in the 4–14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC50s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer.
Company Profile Introduction
Baoji Guokang Health Chemical Technology Co., Ltd has a subsidiary, Baoji Guokang Bio-Technology Co., Ltd. It is located in Baoji High-tech Zone,with epitomizing international, cooperative and honest. We are a young company full of action and energy, our profession improves us rapid progress, which satisfy our clients both in home and abroad. We are specialized in API's intermediates, fine chemicals and plant extracts.We toughly insist on that quality is always the most important item not only for us, but also for our clients. It is believed that we could be considered as the most powerful man in the area of chemicals with combined strength in R&D and Marketing. We are a "customer first" company and believe that our success depends on double-wins.our customers are from more than 160 countries worldwide ,we work closely with every customer to support high quality business service. Our target purpose is "provide favorable value,convenient and flexible solutions for you."we promise: reasonable prices, short supplying period and satisfactory after-sales service. Buyers are welcome to contact us !
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- Since:2018-09-06
- Address: Room B801, Financial Plaza, Jintai District, Baoji, Shaanxi, CN