2-Deoxy-D-glucose CAS 154-17-6

Product Name: 2-Deoxy-D-glucose

CAS: 154-17-6

MF: C6H12O5

MW: 164.16

EINECS: 205-823-0

Melting point 146-147 °C(lit.)

alpha 45.5 º (c=2, H2O)

Boiling point 211.61°C (rough estimate)

density 1.1738 (rough estimate)

refractive index 46.5 ° (C=1, H2O)

storage temp. 0-6°C

Uses

2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.