CAS 84057-84-1 Lamotrigine Anticonvulsant Drug
Price | USD200.00 |
Packge | 1KG |
- Min. Order:1KG
- Supply Ability:5000kg/month
- Time:2022-06-02
Product Details
- Product Namelamotrigine
- CAS No.84057-84-1
- EINECS No.281-901-8
- MFC9H7Cl2N5
- MW256.09
- Appearancepowderwhite
- storage temp. 2-8°C
- Melting point 177-181°C
- Boiling point 503.1±60.0 °C(Predicted)
- density 1.572±0.06 g/cm3(Predicted)
Product Info:
Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected [2]. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels [3]. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated.
General info CAS 84057-84-1 lamotrigine anticonvulsant drug
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