high quality Hydrocortisone with the best price

Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses.

Function:

1). Anti-inflammatory effects: Hydrocortisone has an anti-inflammatory effect of 1.25 times that of cortisone and inhibits both infectious and non-infectious inflammation at pharmacological doses. Hydrocortisone can increase the tension of blood vessels, reduce congestion, and reduce the permeability of capillaries, thus reducing exudation and edema; By inhibiting the aggregation of inflammatory cells(including macrophages and white blood cells) in the inflammatory site, and inhibiting the function of phagocytes, stabilizing the lysosome membrane, preventing the complement from participating in inflammatory reactions and inflammatory chemical agents(such as prostaglandins, thrombosis, and leukotriene) Synthesis and release, In order to relieve red, swollen, hot, pain and other symptoms.

2). Immune inhibition: Including preventing or inhibiting cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, eosinophils, reducing the binding ability of immunoglobulin to cell surface receptors, and inhibiting interleukin synthesis and release, This reduces the conversion of T lymphocytes to lymphatic mother cells and reduces the expansion of the primary immune response. Hydrocortisone and other glucocorticoids can also reduce the passage of immune complexes through the basement membrane, and can reduce the concentration of complement components and immunoglobulin; Can relieve the symptoms of many allergic diseases and inhibit pathological changes caused by allergic reactions, such as allergic congestion, edema, exudation, rash, smooth muscle spasm, and cell damage, which can inhibit the rejection of tissue and organs. For autoimmune diseases can also play a certain short-term effect.

3). Antitoxin effects: Hydrocortisone and other glucocorticoids can improve the body's stress ability for harmful stimuli, reduce the damage of bacterial endotoxins to the body, relieve the symptoms of toxaemia, and have an antipyretic effect on the hyperthermia of toxaemia. The mechanism of antipyretic may be related to the inhibition of the reaction of the body temperature center to pyrolysis, the stabilization of the lysosome membrane, and the reduction of the release of endogenous pyrolysis.

4). Anti-shock effects: Hydrocortisone and other glucocorticoids have a antagonistic effect on toxic shock, hypovolemic shock, and cardiogenic shock. The effect of anti-shock is related to the following factors:(1) dilate the blood vessels and stimulate the heart, strengthen the contractility of the heart; (2) Restrain the production of certain inflammatory factors, reduce systemic inflammatory response syndrome and tissue damage, restore microcirculation hemodynamics to normal, and improve the state of shock; (3) Stabilizing lysosome membranes and reducing the formation of myocardial suppressants:(4) Improving the body's resistance to bacterial endotoxins.

5). Effects on metabolism:(1) Increase liver glycogen and increase blood sugar by promoting glycogen heterogenization, slowing down glucose decomposition, and reducing the use of glucose in body tissues:(2) Improve protein catabolism, Increase the excretion of amino acids in serum and nitrogen in urine, resulting in negative nitrogen balance. And large doses can also inhibit protein synthesis; (3) Can increase plasma cholesterol, activate the esterase under the skin of the limbs, promote the decomposition of subcutaneous fat, and redistribute it on the face, upper chest, back of the neck, abdomen and buttocks, Formed into cardiac obesity:(4) Hydrocortisone has a certain role in the role of corticosteroid, which can increase sodium ion reabsorption and the excretion of potassium, calcium, and phosphorus.

6). Effects on the blood and hematopoietic system: It can stimulate the hematopoietic function of the bone marrow, increase the content of red blood cells and hemoglobin, and large doses may increase platelets and increase fibrinogen concentration, shortening coagulation time. In addition, it can reduce the number of acidophilic granulocytes and lymphocytes in the blood.

7). Other: Can reduce the pathological proliferation of connective tissue, increase the excitement of the central nervous system, promote gastric acid and pepsin secretion, etc..