94-62-2
Product Name:
Piperine
Formula:
C17H19NO3
Synonyms:
(E,E)-5-(3,4-Methylenedioxyphenyl)-2,4-pentadienoylpiperidide;1-Piperoylpiperidine;Piperine
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Light yellow to yellow solid with a pungent odor; [Reference #1] Light yellow solid; [Sigma-Aldrich MSDS] |
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Boiling Point | 498.00 to 499.00 °C. @ 760.00 mm Hg |
Melting Point | 129 °C |
Solubility | 0.04 mg/mL at 18 °C |
Vapor Pressure | 0.00000013 [mmHg] |
Collision Cross Section | 171.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
Kovats Retention Index | 2933 2835 |
Chemical Classes | Other Uses -> Food Additives |
SAFETY INFORMATION
Signal word | Warning |
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Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H411:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
Molecular Weight | 285.34 g/mol |
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XLogP3 | 3.5 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 3 |
Exact Mass | 285.13649347 g/mol |
Monoisotopic Mass | 285.13649347 g/mol |
Topological Polar Surface Area | 38.8 Ų |
Heavy Atom Count | 21 |
Formal Charge | 0 |
Complexity | 412 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 2 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Piperine is a N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite. It is a member of benzodioxoles, a N-acylpiperidine, a piperidine alkaloid and a tertiary carboxamide. It is functionally related to an (E,E)-piperic acid.