846-49-1
Product Name:
Lorazepam
Formula:
C15H10Cl2N2O2
Synonyms:
(±)-Lorazepam;7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
---|---|
Boiling Point | 533.8 ºC at 760 mm Hg |
Melting Point | 192-194 |
Solubility | 80 mg/L |
LogP | 2.39 |
LogS | -3.6 |
Caco2 Permeability | 200 |
Dissociation Constants | 13 |
Collision Cross Section | 165.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
Kovats Retention Index | 2426 2375 2375 2380 2423 2423 2448 2384 2430 2399 2411 2442 2430 2440 2402 2402 2448 2410 2403.2 2391 2430 2395 2402 2415.3 |
SAFETY INFORMATION
Signal word | Warning |
---|---|
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
Molecular Weight | 321.2 g/mol |
---|---|
XLogP3 | 2.4 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 1 |
Exact Mass | 320.0119330 g/mol |
Monoisotopic Mass | 320.0119330 g/mol |
Topological Polar Surface Area | 61.7 Ų |
Heavy Atom Count | 21 |
Formal Charge | 0 |
Complexity | 443 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Lorazepam is a benzodiazepine.