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845272-21-1

845272-21-1 structural image
Product Name: ARRY-334543
Formula: C22H19ClN6O2S
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COMPUTED DESCRIPTORS

Molecular Weight 466.9 g/mol
XLogP3 4.2
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 7
Exact Mass 466.0978727 g/mol
Monoisotopic Mass 466.0978727 g/mol
Topological Polar Surface Area 122 Ų
Heavy Atom Count 32
Formal Charge 0
Complexity 660
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Varlitinib is an oral, selective, reversible, small molecule tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR. Over-expression of ErbB-2 and EGFR receptors in tumors is predictive of poor prognosis in cancer patients. Varlitinib has shown significant anti-tumor activity in preclinical models of human breast, lung, and epidermal carcinoma tumors.