77-67-8
Product Name:
ETHOSUXIMIDE
Formula:
C7H11NO2
Synonyms:
2-Ethyl-2-methylsuccinimide;Ethosuximide
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Crystals from acetone and ether |
| Odor | CHARACTERISTIC ODOR |
| Melting Point | 64.5 °C |
| Solubility | 39.2 g/L |
| LogP | 0.38 |
| Stability/Shelf Life | Commercially available capsules have an expiration date of 5 years and the oral solution has an expiration date of 4 years following the date of manufacture. |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxide/. |
| Kovats Retention Index | 1192 1193 1193 1193 1194 1194 1220 1225 1190 1196 1210 1205.4 1184 1189 1206 1220 1220 |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 141.17 g/mol |
|---|---|
| XLogP3 | 0.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 141.078978594 g/mol |
| Monoisotopic Mass | 141.078978594 g/mol |
| Topological Polar Surface Area | 46.2 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 188 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Ethosuximide is a dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures. It has a role as an anticonvulsant, a geroprotector and a T-type calcium channel blocker. It is a pyrrolidinone and a dicarboximide.