738-70-5
Product Name:
Trimethoprim
Formula:
C14H18N4O3
Synonyms:
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine;NSC 106568
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CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Trimethoprim is an odorless white powder. Bitter taste. (NTP, 1992) |
|---|---|
| Color/Form | White to cream, crystalline powder |
| Odor | Odorless |
| Taste | Bitter |
| Melting Point | 390 to 397 °F (NTP, 1992) |
| Solubility | less than 1 mg/mL at 75 °F (NTP, 1992) |
| LogP | 0.91 |
| LogS | -2.86 |
| Stability/Shelf Life | The solubility of trimethoprim in aqueous solns is partially dependent on the pH of the soln. Trimethoprim is a weak base, & its solubility is lower in solns with a more alkaline pH. |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxide/. |
| Dissociation Constants | 7.12 (at 20 °C) |
| Collision Cross Section | 170.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2564 2574 2564.7 |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 290.32 g/mol |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 5 |
| Exact Mass | 290.13789045 g/mol |
| Monoisotopic Mass | 290.13789045 g/mol |
| Topological Polar Surface Area | 106 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 307 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Trimethoprim is an antibiotic used to treat bacterial infections. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu).