39455-18-0
Product Name:
Chondroitin sulfate A sodium salt
Formula:
(C14H19NO14SNa2)n
Synonyms:
Alternating Copoly β-glucuronic acid-(1→3)-N-acetyl-β-galactosamine-4-sulfate-(1→4)
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Melting Point | 190-194ºC |
|---|---|
| Solubility | Soluble |
| Dissociation Constants | 1.5-2 |
COMPUTED DESCRIPTORS
| Molecular Weight | 463.37 g/mol |
|---|---|
| XLogP3 | -4.8 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 6 |
| Exact Mass | 463.06319014 g/mol |
| Monoisotopic Mass | 463.06319014 g/mol |
| Topological Polar Surface Area | 267 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 739 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 10 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific patterns. Depending on the predominating disaccharide unit, it will present different biological activities. Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.