3680-69-1
Product Name:
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Formula:
C6H4ClN3
Synonyms:
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
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SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
PRODUCT INTRODUCTION
description
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine might be a practical building block in the synthesis of many JAK inhibitors. It is synthesis as follows:
A mixture of compound 6-Chloro-5-(2,2-diethoxyethyl)pyrimidin-4-amine (10.0 g, 41 mmol) and 6 M HCl (30 ml) in petroleum ether (30 ml) was stirred at 50°C for 4 h. The mixture was filtered to give the solid crude 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, which was oven-dried and triturated with a mixture of petroleum ether – EtOAc, 1:1. Yield 5.68 g (91%), white solid.
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