315-30-0
Product Name:
Allopurinol
Formula:
C5H4N4O
Synonyms:
1H-Pyrazolo(3,4-d)pyrimidin-4-ol;4-Hydroxypyrazolo(3,4-d)pyrimidine;4-Hydroxypyrazolo[3,4-d]pyrimidine;Allopurinol;HPP
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SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
PRODUCT INTRODUCTION
Description
Allopurinol, a structural analog of hypoxanthine, is used primarily to treat hyperuricaemia and gout. Due to its inhibition of xanthine oxidase (E.C.1.2.3.2.), the enzyme that catalyzes the production of xanthine from hypoxanthine and uric acid from xanthine, both the plasma level of uric acid and its renal excretion is reduced. Allopurinol is a blocker and a substrate of xanthine oxidase; the oxidized metabolite, oxipurinol or alloxanthine, is also a potent inhibitor of xanthine oxidase. Recently, several new indications for allopurinol have emerged, for instance, prevention of tissue damage due to free radical formation, prevention of urinary stones, and treatment of protozoal diseases.