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17560-51-9

17560-51-9 structural image
Product Name: Metolazone
Formula: C16H16ClN3O3S
Synonyms: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form CRYSTALS FROM ETHANOL
Odor ODORLESS
Taste TASTELESS
Melting Point 256 °C
Solubility 60.3 mg/L (at 25 °C)
LogP 2.5
LogS -3.78
Stability/Shelf Life LIGHT-SENSITIVE
Dissociation Constants PKA: 9.72
Collision Cross Section 181.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Other Experimental Properties ALSO REPORTED AS MP 246-250 °C (US PATENT 3,557,111)

COMPUTED DESCRIPTORS

Molecular Weight 365.8 g/mol
XLogP3 4.1
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 2
Exact Mass 365.0600902 g/mol
Monoisotopic Mass 365.0600902 g/mol
Topological Polar Surface Area 101 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 594
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Metolazone is a quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics. It has a role as a diuretic, an antihypertensive agent and an ion transport inhibitor. It is a member of quinazolines, an organochlorine compound and a sulfonamide.

RELATED SUPPLIERS

KARPSCHEM LABORATORIES PVT. LTD.

1Y
product:17560-51-9 Metolazone 7- Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6 quinazolinesulfonamide 96%

Centaur Pharmaceuticals Pvt Ltd

1Y
product:17560-51-9 99%
All suppliers(3)