CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid; [Merck Index] |
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Color/Form | Crystals |
Melting Point | MP: 103-105 °C /Monensin monohydrate/ |
Solubility | Slightly soluble in water |
Stability/Shelf Life | Stable under recommended storage conditions. /Monensin sodium salt/ |
Decomposition | When heated to decomposition it emits acrid smoke & irritating fumes. |
Dissociation Constants | pKa = 6.6 (in 66% N,N-dimethylformamide) |
Collision Cross Section | 245.1 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
Other Experimental Properties | Very stable under alkaline conditions. |
Chemical Classes | Biological Agents -> Bacterial Toxins |
COMPUTED DESCRIPTORS
Molecular Weight | 670.9 g/mol |
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XLogP3 | 4.2 |
Hydrogen Bond Donor Count | 4 |
Hydrogen Bond Acceptor Count | 11 |
Rotatable Bond Count | 10 |
Exact Mass | 670.42921279 g/mol |
Monoisotopic Mass | 670.42921279 g/mol |
Topological Polar Surface Area | 153 Ų |
Heavy Atom Count | 47 |
Formal Charge | 0 |
Complexity | 1110 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 17 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Monensin A is a spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle. It has a role as a coccidiostat, an antifungal agent and an ionophore. It is a monocarboxylic acid, a cyclic hemiketal, a spiroketal and a polyether antibiotic.