CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Color/Form | Solid |
Melting Point | 160-160.5 °C |
Solubility | 158 mg/L |
LogP | 0 |
Stability/Shelf Life | Solutions of cephalothin may darken, especially if stored at room temperature. A slight discoloration does not affect potency. Solutions stored under refrigeration may precipitate, but the precipitate can be redissolved by warming to room temperature with constant agitation. |
Optical Rotation | Mol wt 418.42. mp 204-205 °C. Specific optical rotation = +135 °For D sodium line (c = 1.0 in water). uv max: 236, 260 nm (epsilon 12950, 9350) /Sodium salt/ |
Decomposition | When heated to decomposition it emits very toxic fumes of nitroxides and sulfoxides. |
SAFETY INFORMATION
Signal word | Warning |
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Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P285:In case of inadequate ventilation wear respiratory protection. P363:Wash contaminated clothing before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P341:IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. P403:Store in a well-ventilated place. |
COMPUTED DESCRIPTORS
Molecular Weight | 396.4 g/mol |
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XLogP3 | -0.4 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 8 |
Rotatable Bond Count | 7 |
Exact Mass | 396.04497858 g/mol |
Monoisotopic Mass | 396.04497858 g/mol |
Topological Polar Surface Area | 167 Ų |
Heavy Atom Count | 26 |
Formal Charge | 0 |
Complexity | 680 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 2 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Cefalotin is a semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections. It has a role as an antimicrobial agent and an antibacterial drug. It is a semisynthetic derivative, a beta-lactam antibiotic allergen, a cephalosporin, a carboxylic acid, a member of thiophenes and an azabicycloalkene. It is a conjugate acid of a cefalotin(1-).