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144060-53-7

144060-53-7 structural image
Product Name: Febuxostat
Formula: C16H16N2O3S
Synonyms: 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid;Adenuric;Atenuri;Uloric
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CHEMICAL AND PHYSICAL PROPERTIES

Melting Point 238-239°
Solubility <1 mg/mL
Collision Cross Section 180.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

COMPUTED DESCRIPTORS

Molecular Weight 316.4 g/mol
XLogP3 3.9
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 5
Exact Mass 316.08816355 g/mol
Monoisotopic Mass 316.08816355 g/mol
Topological Polar Surface Area 111 Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 448
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Febuxostat is a 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout. It has a role as an EC 1.17.3.2 (xanthine oxidase) inhibitor. It is an aromatic ether, a nitrile and a 1,3-thiazolemonocarboxylic acid.

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GLP Pharma Standards

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KARPSCHEM LABORATORIES PVT. LTD.

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Metrochem API Private Limited

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Hetero Drugs Limited

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