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112901-68-5

112901-68-5 structural image
Product Name: Anifostine trihydrate
Formula: C5H17N2O4PS
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SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

COMPUTED DESCRIPTORS

Molecular Weight 268.27 g/mol
Hydrogen Bond Donor Count 7
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 268.08579457 g/mol
Monoisotopic Mass 268.08579457 g/mol
Topological Polar Surface Area 124 Ų
Heavy Atom Count 15
Formal Charge 0
Complexity 152
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 4
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Amifostine is the trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.